"the Inheritance of ‘high Uric Acid Excretion’ in Dogs”
نویسنده
چکیده
and graphics by Carroll H. Weiss Former Director (1991-2002) DCA Study Group on Urinary Stones
منابع مشابه
Nucleotide metabolism and Urate excretion in the Dalmatian dog breed
The purpose of this literature study is to give an overview of nitrogen and purine metabolism in general and in particular of the molecular mechanisms for the higher uric acid excretion in Dalmatian dogs. The character portrayed by the Dalmatian breed appears to be connected whit a malfunction within purine metabolism, some studies point at a kidney disease whereas other at a liver disease. Alt...
متن کاملThe utility of uric acid assay in dogs as an indicator of functional hepatic mass.
Uric acid was used as a test for liver disease before the advent of enzymology. Three old studies criticised uric acid as a test of liver function. Uric acid, as an end-product of purine metabolism in the liver, deserved re-evaluation as a liver function test. Serum totalbile acids are widely accepted as the most reliable liver function test. This study compared the ability of serum uric acid c...
متن کاملGas chromatography-mass spectrometric studies of canine urinary metabolism.
After the urine was treated with urease, lyophilized, and trimethylsilylated, it was examined for metabolic profiles in Dalmatian dogs and Shetland sheepdogs by gas chromatography-mass spectrometry (GC/MS), which simultaneously analyzes organic acids, amino acids, sugars, sugar alcohols, purine and pyrimidine bases, and nucleosides. The profiles were compared with those from human specimens. As...
متن کاملEvaluation of Serum Uric Acid and Glutathione Levels in Diabetic Patients and Healthy Subjects
Objective: It is well known that diabetes is one of the main health challenges. According to the evidence presented in recent years by investigators, serum uric acid has emerged as a possible risk factor for diabetes mellitus. The aim of the present study was to compare the mean serum uric acid and the antioxidant activity of glutathione levels in patients with diabetes and the control group. ...
متن کاملInheritance of urinary calculi in the Dalmatian.
Dalmatians are unique among dogs in that they excrete uric acid in their urine as the end product of purine metabolism rather than allantoin as do other breeds of dogs. Urinary calculi form from urate (salts of uric acid) and can cause urethral obstruction in male Dalmatians. Although all Dalmatians have the primary defect, only a subset develops clinical disease. We postulated that calculi for...
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